circRNA basic information
circBase ID: hsa_circ_0008259
Name: hsa_circ_LMO7
Synonym: circ_0008259
Host Gene: hsa-miR-21-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteoblast cells (hFOB1.19), OS cell lines (143B, HOS, U2OS, MG63)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-21-5p
Biological function: Functional experiments showed that circ_0008259 overexpression significantly inhibited the proliferation and metastatic potential of OS cells and promoted the apoptosis.
Molecular mechanism: PDCD4 was validated as the target gene of hsa-miR-21-5p, and circ_0008259 could competitively bind to hsa-miR-21-5p, thus up-regulating PDCD4 expression in OS cells.
Survival: -
Supported No.:
 1
Description:

Circ_0008259 suppresses OS progression via regulating miR-21-5p/PDCD4 axis.
Other information
Title:

Hsa_circ_0008259 modulates miR-21-5p and PDCD4 expression to restrain osteosarcoma progression.

Journal: Aging (Albany NY)
Published: 2021/12/15
PubMed ID: 34905503