circRNA basic information
circBase ID: -
Name: hsa_circ_ATP2A2
Synonym: circATP2A2
Host Gene: hsa-miR-335-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OS cell lines (U2OS, HOS, Saos-2), hFOB1.19 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-335-5p
Biological function: circATP2A2 silencing repressed OS cell proliferation and glycolysis_n vivo_nd constrained OS cell proliferation, glycolysis, migration, and invasion_n vitro.
Molecular mechanism: circATP2A2 regulated MYH9 expression through sponging hsa-miR-335-5p. hsa-miR-335-5p inhibitor reversed the repressive effect of circATP2A2 knockdown on OS cell malignancy and glycolysis. MYH9 overexpression overturned hsa-miR-335-5p upregulation-mediated OS cell malignancy and glycolysis.
Survival: -
Supported No.:
 2
Description:

circATP2A2 accelerated OS cell malignancy and glycolysis through upregulating MYH9 via sponging miR-335-5p, offering a promising target for OS treatment.
Other information
Title:

circATP2A2 promotes osteosarcoma progression by upregulating MYH9.

Journal: Open Med (Wars)
Published: 2021/12/14
PubMed ID: 34901459