circRNA basic information
circBase ID: hsa_circ_0023305
Name: hsa_circ_CCND1
Synonym: circ_0023305
Host Gene: hsa-miR-218-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: AMC-HN-8, Hep-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-218-5p
Biological function: Knockdown of hsa_circ_0023305 significantly inhibited LSCC cell proliferation, invasion, and migration abilities.
Molecular mechanism: hsa_circ_0023305 functioned as a hsa-miR-218-5p sponge from a mechanistic perspective, targeting the melastatin-related transient receptor potential 7 (TRPM7) in LSCC cells. TRPM7 regulates a nonselective cation channel and promotes cancer proliferation and metastasis. Our data demonstrated that hsa-miR-218-5p was downregulated in LSCC and that hsa-miR-218-5p upregulation repressed LSCC proliferation and invasion both_n vivo_nd_n vitro. Additionally, we found that hsa_circ_0023305-mediated upregulation of TRPM7 inhibited hsa-miR-218-5p and contributed to LSCC migration, proliferation, and invasion.
Survival: poor
Supported No.:
 2
Description:

In summary, these data propose a new mechanism by which the hsa_circ_0023305/miR-218-5p/TRPM7 network enhances LSCC progression.
Other information
Title:

hsa_circ_0023305 Enhances Laryngeal Squamous Cell Carcinoma Progression and Modulates TRPM7 via miR-218-5p Sponging.

Journal: Biomed Res Int
Published: 2021/12/14
PubMed ID: 34901284