circRNA basic information
circBase ID: -
Name: hsa_circ_CORO1C
Synonym: Circ_CORO1C
Host Gene: hsa-miR-654-3p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LSCC cell lines (TU-177, FD-LSC-1 cells), human oral keratinocytes cells (HOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-654-3p
Biological function: circ_CORO1C silencing constrained cell proliferation and promoted apoptosis via reducing cell proliferation, inducing cell cycle arrest, inhibiting epithelial-mesenchymal transition, and promoting apoptosis, as well as restraining cell migration and invasion.
Molecular mechanism: circ_CORO1C regulated USP7 expression by modulating hsa-miR-654-3p.
Survival: -
Supported No.:
 2
Description:

In conclusion, circ_CORO1C is highly expressed in LSCC tissues and cells, and circ_CORO1C silencing repressed LSCC progression via regulating miR-654-3p/USP7 axis.
Other information
Title:

CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.

Journal: Biochem Genet
Published: 2022/1/23
PubMed ID: 35064359