circRNA basic information
circBase ID: hsa_circ_0000423
Name: -
Synonym: circ_0000423
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: a human renal epithelial cell line (293_), 4 kinds of GC cell lines (HGC-27, AGS, MGC-803, MKN-45), a human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-582-3p
Biological function: circ_0000423 was highly expressed in GC. Circ_0000423 knockdown suppressed GC cell viability, migration and invasion.
Molecular mechanism: hsa-miR-582-3p was confirmed as a direct target of circ_0000423, and an upstream regulator of DIXDC1. hsa-miR-582-3p inhibition or DIXDC1 overexpression could reverse the above-mentioned effects of knocking down circ_0000423 on GC cells.
Survival: -
Supported No.:
 1
Description:

circ_0000423 facilitates GC progression by modulating the miR-582-3p/DIXDC1 axis.
Other information
Title:

Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis.

Journal: Bioengineered
Published: 2021/12/14
PubMed ID: 34898351