circRNA basic information
circBase ID: hsa_circ_0058493
Name: hsa_circ_RHBDD1
Synonym: circ_0058493
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (BEL-7404, HCCLM3, SK-Hep-1, SMMC-7721, MHCC-97H) together with a normal liver cell line (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Experimentally, hsa_circ_0058493 knockdown suppressed the growth and metastasis of HCC cells_n vivo_nd_n vitro. On the contrary, the overexpression of hsa_circ_0058493 in HCC cells had the opposite effect_n vitro.
Molecular mechanism: Mechanistic experiments revealed that hsa_circ_0058493 contained m6A methylation sites and that methyltransferase-like 3 (METTL3) mediated the degree of methylation modification of hsa_circ_0058493. Furthermore, YTH domain-containing protein 1 (YTHDC1) could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm. In addition, both si-METTL3 and si-YTHDC1 suppressed HCC cell growth and metastasis, whereas rescue experiments confirmed that overexpression of hsa_circ_0058493 inverted the inhibitory effects of si-METTL3 and si-YTHDC1 on HCC cells.
Survival: -
Supported No.:
 2
Description:

Taken together, this study explored the oncogenic role of m6A-modified hsa_circ_0058493 and found to accelerate HCC progression via the METTL3-hsa_circ_0058493-YTHDC1 axis, indicating a potential therapeutic target for this deadly disease.
Other information
Title:

Methyltransferase-Like 3-Mediated m6A Methylation of Hsa_circ_0058493 Accelerates Hepatocellular Carcinoma Progression by Binding to YTH Domain-Containing Protein 1.

Journal: Front Cell Dev Biol
Published: 2021/12/11
PubMed ID: 34888309