circRNA basic information
circBase ID: -
Name: -
Synonym: circ_0075943
Host Gene: hsa-miR-141-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal breast epithelial cell lines (MCF-10A), human BC cell lines (MCF-7, MDA-MB-231, MDA-MB-468, BT-474)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AK2
Associated microRNA: hsa-miR-141-3p
Biological function: Dwindling of circ_0075943 could dramatically suppress the phenotype of BC cells and induce apoptosis.
Molecular mechanism: hsa-miR-141-3p is a target of circ_0075943, and its repression largely reverses the influence of knocking down circ_0075943 on cell behavior. Moreover, AK2, as a target of hsa-miR-141-3p, is augmented in BC cells and specimens. AK2 overexpression could restore the phenotype of BC cells blocked by hsa-miR-141-3p redevelopment. Moreover, knocking down circ_0075943 could suppress the growth of tumors in vivo.
Survival: -
Supported No.:
 1
Description:

The abnormal regulation of circ_0075943 participates in part of the expansion of BC by dominating the miR-141-3p/AK2 regulatory network.
Other information
Title:

circ_0075943 Dominates the miR-141-3p/AK2 Network to Support the Development of Breast Carcinoma.

Journal: J Oncol
Published: 2021/12/11
PubMed ID: 34887922