circRNA basic information
circBase ID: hsa_circ_0073748
Name: hsa_circ_LMNB1
Synonym: circ_0073748
Host Gene: hsa-miR-132-3p
 
 
 
Disease basic information
DO ID:
 2913
DO name: acute pancreatitis
Disease details: acute pancreatitis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human pancreatic ductal HPDE6-C7 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-132-3p
Biological function: Silencing circ_0073748 alleviated caerulein-induced pancreatic ductal cell injury
Molecular mechanism: hsa-miR-132-3p was downregulated in AP and targeted by circ_0073748, Exhausting hsa-miR-132-3p contributed to caerulein-induced injury in pancreatic ductal cells with circ_0073748 silencing, hsa-miR-132-3p targeted TRAF3 in HPDE6-C7 cells, Reinforcing TRAF3 abated the restraining effect of hsa-miR-132-3p on caerulein-induced pancreatic ductal cell injury, Circ_0073748 interference suppressed caerulein-activated canonical NF-kappaB signal via regulating hsa-miR-132-3p and TRAF3
Survival: -
Supported No.:
 1
Description:

circ_0073748/miR-132-3p/TRAF3 ceRNA pathway might be one underlying mechanism and therapeutic target of caerulein-induced AP.
Other information
Title:

Interfering hsa_circ_0073748 alleviates caerulein-induced ductal cell injury in acute pancreatitis by inhibiting miR-132-3p/TRAF3/NF-kappaB pathway.

Journal: Cell Cycle
Published: 2021/12/10
PubMed ID: 34882521