circRNA basic information
circBase ID: hsa_circ_0008594
Name: -
Synonym: circ_0008594
Host Gene: hsa-miR-760
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: H23, H460 cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-760
Biological function: circ_0008549 affected H23 and H460 cell proliferation and apoptosis
Molecular mechanism: circ_0008594 promoted H23 and H460 cell proliferation and invasion but affected stemness less and negatively regulated hsa-miR-760_ia_irect binding. Furthermore, hsa-miR-760 attenuated the effect of circ_0008549 on regulating H23 and H460 cell functions and the PI3K/AKT and MEK/ERK pathways._n vivo_xperiments further confirmed that circ_0008549 increased tumor volume, epithelial-mesenchymal transition, and the PI3K/AKT and MEK/ERK pathways while reducing tumor apoptosis and hsa-miR-760 NSCLC xenograft models.
Survival: -
Supported No.:
 1
Description:

Our study identifies several valuable circRNAs related to NSCLC development and LNM. Furthermore, as a key functional circRNA, circ_0008594 was observed to promote NSCLC progression by regulating the miR-760-mediated PI3K/AKT and MEK/ERK pathways.
Other information
Title:

Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways.

Journal: Front Oncol
Published: 2021/12/4
PubMed ID: 34858831