circRNA basic information
circBase ID: -
Name: hsa_circ_ATAD1
Synonym: Circ-ATAD1
Host Gene: hsa-miR-154-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Hs 3.T, MG-63, normal bone cell line (Hfob1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-154-5p
Biological function: Transwell assay analysis showed that circ-ATAD1 overexpression increased cell invasion and migration, and mature miR-154-5p overexpression suppressed these cell behaviors. In addition, circ-ATAD1 overexpression reduced the effects of mature miR-154-5p overexpression on cell behaviors.
Molecular mechanism: Mature hsa-miR-154-5p, but not premature hsa-miR-154-5p, was downregulated in OS tissues compared to non-tumor tissues and was inversely correlated with circ-ATAD1. In OS cells, circ-ATAD1 overexpression decreased the expression of mature hsa-miR-154-5p, but not premature hsa-miR-154-5p.
Survival: -
Supported No.:
 1
Description:

Circ-ATAD1 is overexpressed in OS and suppresses miR-154-5p maturation to increase cell invasion and migration.
Other information
Title:

Circ-ATAD1 is overexpressed in osteosarcoma (OS) and suppresses the maturation of miR-154-5p to increase cell invasion and migration.

Journal: J Orthop Surg Res
Published: 2021/12/4
PubMed ID: 34857012