circRNA basic information
circBase ID: hsa_circ_0059354
Name: hsa_circ_RASSF2
Synonym: Circ_0059354
Host Gene: hsa-miR-766-3p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Nthy-ori 3_1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-766-3p
Biological function: circ_0059354 silencing suppressed cell proliferation, migration, invasion and angiogenesis and facilitated apoptosis in PTC cells.
Molecular mechanism: Circ_0059354 was identified to sponge hsa-miR-766-3p, which directly targeted ARFGEF1. Moreover, circ_0059354 directly targeted hsa-miR-766-3p to positively regulated ARFGEF1 expression. hsa-miR-766-3p inhibition reversed circ_0059354 knockdown-mediated effect of PTC cell malignant behaviors. Overexpression of hsa-miR-766-3p restrained the malignant behaviors of PTC cells, whereas ARFGEF1 elevation reversed the effects. Additionally, circ_0059354 deficiency blocked tumor growth in vivo.
Survival: -
Supported No.:
 2
Description:

Circ_0059354 served as an oncogene in PTC progression through regulating miR-766-3p/ARFGEF1 axis.
Other information
Title:

Circ_0059354 aggravates the progression of papillary thyroid carcinoma by elevating ARFGEF1 through sponging miR-766-3p.

Journal: J Endocrinol Invest
Published: 2021/12/3
PubMed ID: 34854069