circRNA basic information
circBase ID: hsa_circ_0003949
Name: hsa_circ_PTN
Synonym: circ_PTN
Host Gene: hsa-miR-542-3p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U87R, U251R
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PIK3R3
Associated microRNA: hsa-miR-542-3p
Biological function: The expression of circ_PTN in DDP-sensitive and DDP-resistant GBM cells was detected in our assay. Functional experiments were utilized to unveil the effects of circ_PTN on the DDP resistance of GBM cells.
Molecular mechanism: Mechanism assays were conducted to confirm the mechanism of how circ_PTN affected the DDP resistance of GBM cells. According to the results, we found that circ_PTN promoted the DDP resistance of GBM cells through activation of the PI3K/AKT pathway. Moreover, circ_PTN silencing inhibited the DDP resistance of GBM tumors_n vivo.
Survival: poor
Supported No.:
 1
Description:

To conclude, our study unveiled the influence of circ_PTN on the DDP resistance of GBM cells, which might provide a therapeutic target for GBM treatment via DDP.
Other information
Title:

circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway.

Journal: Mol Ther Nucleic Acids
Published: 2021/12/3
PubMed ID: 34853725