circRNA basic information
circBase ID: -
Name: hsa_circ_ATP10A
Synonym: circ-ATP10A
Host Gene: hsa-miR-6758-3p, hsa-miR-3977, hsa-miR-6804-3p, hsa-miR-1266-3p, hsa-miR-3620-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma angiogenesis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-6758-3p, hsa-miR-3977, hsa-miR-6804-3p, hsa-miR-1266-3p, hsa-miR-3620-3p
Biological function: qRT-PCR confirmed that the expression of circ-ATP10A was significantly increased in MM patients.
Molecular mechanism: The bioinformatics analyses suggested that circ-ATP10A can act as a microRNA (miRNA) sponge and regulate the expression of downstream vascular endothelial growth factor-B (VEGFB), hypoxia-inducible factor-1alpha (HIF1A), platelet-derived growth factor subunit A (PDGFA), and fibroblast growth factor (FGF). The immunohistochemical results indicated that the circ-ATP10A level was positively correlated with the protein levels of VEGFB and marrow microvessel density (MVD) in MM patients, and the receiver operating characteristic (ROC) curve, area under the ROC curve (AUC) and Kaplan-Meier survival curve analyses confirmed it as a prognostic biomarker.
Survival: poor
Supported No.:
 1
Description:

Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR-6758-3p/hsa-miR-3977/hsa-miR-6804-3p/hsa-miR-1266-3p/hsa-miR-3620-3p and modulating their downstream mRNAs, such as VEGFB, HIF1A, PDGF, and FGF.
Other information
Title:

A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis.

Journal: Bioengineered
Published: 2021/12/3
PubMed ID: 34852710