circRNA basic information
circBase ID: hsa_circ_0030586
Name: hsa_circ_ABCC4
Synonym: circ_0030586
Host Gene: hsa-miR-145-3p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: RWPE-1, DU145, PC3, 22Rv1, LNCaP, PC-3_-2B4, PC-3_-IE8
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-145-3p
Biological function: Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion and led to the significant upregulation of E-cadherin and the significant downregulation of p-AKT/AKT, IKKalpha, PIK3CB, and Twist (all p < 0.05).
Molecular mechanism: the hsa_circ_003058 interference fragment combined with the transfection of a hsa-miR-145-3p inhibitor could reverse the above effects. In vivo tumorigenesis of the xenograft model confirmed that interfering with hsa_circ_0030586 suppressed tumor cell proliferation and inhibited PI3K-AKT signaling and EMT in PC3 cells.
Survival: -
Supported No.:
 2
Description:

Hsa_circ_0030586 is significantly upregulated in PCa cells and may promote EMT via PI3K-AKT signaling.
Other information
Title:

Hsa_circ_0030586 promotes epithelial-mesenchymal transition in prostate cancer via PI3K-AKT signaling.

Journal: Bioengineered
Published: 2021/12/3
PubMed ID: 34852706