Detected method: |
Q
|
Detected method confidence |
High
|
Expression pattern: |
|
Associated gene: |
- |
Associated microRNA: |
hsa-miR-320-3p |
Biological function: |
The expression of circ_UTRN was decreased by caerulein in pancreatic acinar cells, ectopic overexpression of circ_UTRN reduced inflammation and promoted apoptosis in caerulein-mediated pancreatic acinar cells |
Molecular mechanism: |
circ_UTRN served as a sponge of hsa-miR-320-3p, and hsa-miR-320-3p directly targeted PTK2. Rescue assay suggested that the promotion of apoptosis and inhibition of inflammation induced by circ_UTRN re-expression in caerulein-mediated pancreatic acinar cells were partially abolished by hsa-miR-320-3p overexpression or PTK2 knockdown. Besides that, hsa-miR-320-3p inhibition impaired caerulein-induced cell apoptosis arrest and inflammation via targeting PTK2. |
Survival: |
- |
Supported
No.: |
1 |
Description: |
Up-regulation of circ_UTRN in pancreatic acinar cells attenuates caerulein-evoked cell apoptosis arrest and inflammation enhancement via miR-320-3p/PTK2, suggesting that circ_UTRN/miR-320-3p/PTK2 axis might be engaged in caerulein-induced AP. |