circRNA basic information
circBase ID: -
Name: hsa_circ_VAPA
Synonym: circVAPA
Host Gene: hsa-miR-342-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (Calu-3, Calu-6, A549, H1299), normal human bronchial epithelial cell lines (HBE1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-342-3p
Biological function: circVAPA silencing suppressed the proliferation, migration, and invasion and induced the apoptosis of NSCLC cells.
Molecular mechanism: CircVAPA served as a molecular sponge for microRNA-342-3p (hsa-miR-342-3p). hsa-miR-342-3p interference largely reversed circVAPA knockdown-mediated anti-tumor effects in NSCLC cells. Zinc finger E-box-binding homeobox 2 (ZEB2) was a target of hsa-miR-342-3p, and hsa-miR-342-3p overexpression suppressed the malignant behaviors of NSCLC cells largely by downregulating ZEB2. CircVAPA silence repressed xenograft tumor growth in vivo, and IHC assay confirmed that circVAPA silence restrained the proliferation and metastasis but induced the apoptosis of NSCLC cells in vivo.
Survival: poor
Supported No.:
 2
Description:

CircVAPA contributes to the progression of NSCLC by binding to miR-342-3p to upregulate ZEB2. CircVAPA/miR-342-3p/ZEB2 axis might be a novel potential target for NSCLC treatment.
Other information
Title:

Circular RNA circVAPA contributes to non-small-cell lung cancer progression via miR-342-3p-dependent regulation of ZEB2.

Journal: World J Surg Oncol
Published: 2021/11/30
PubMed ID: 34839824