circRNA basic information
circBase ID: -
Name: hsa_circ_TMEM181
Synonym: circTMEM181
Host Gene: hsa-miR-488-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: P.R.C. Cell lines (HepG2, HCCLM3, MHC97H, Huh-7, PLC/PRF/5, H22, Hepa1-6)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-488-3p
Biological function: circTMEM181 was elevated in hepatocellular carcinoma (HCC) patients responding poorly to anti-PD1 therapy and in HCC patients with a poor prognosis after operation. high exosomal circTMEM181 favored the immunosuppressive microenvironment and endowed anti-PD1 resistance in HCC.
Molecular mechanism: exosomal circTMEM181 sponged hsa-miR-488-3p and upregulated CD39 expression in macrophages.cell-specific CD39 expression in macrophages and CD73 expression in HCC cells synergistically activated the eATP-adenosine pathway and produced more adenosine, thereby impairing CD8+ T cell function and driving anti-PD1 resistance.
Survival: poor
Supported No.:
 2
Description:

In summary, HCC-derived exosomal circTMEM181 contributes to immunosuppression and anti-PD1 resistance by elevating CD39 expression, and inhibiting the ATP-adenosine pathway by targeting CD39 on macrophages can rescue anti-PD1 therapy resistance in HCC.
Other information
Title:

Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma.

Journal: J Hematol Oncol
Published: 2021/11/29
PubMed ID: 34838121