circRNA basic information
circBase ID: hsa_circ_0000517
Name: -
Synonym: circ_0000517
Host Gene: hsa-miR-326, hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal bronchial epithelial cell line (BEAS-2B), NSCLC cell lines (H1650, H1299, A549, H1975, HCC827)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MMP2
Associated microRNA: hsa-miR-326, hsa-miR-330-5p
Biological function: The up-regulation of_irc_0000517_s closely associated with advanced clinical stage of cancer, lymph node metastasis, and poor prognosis in NSCLC patients._irc_0000517_nockdown impeded the proliferation, migration, and invasion of NSCLC cells and enhanced their apoptosis.
Molecular mechanism: circ_0000517_as demonstrated to up-regulate MMP2 expression via decoying_iR-326_nd_iR-330-5p_o facilitate the malignant biological behaviors of NSCLC cells.
Survival: poor
Supported No.:
 2
Description:

This work reveals that_irc_0000517_s implicated in NSCLC cell growth and metastasis through the modulation of miR-326/miR-330-5p/MMP2, providing novel insights into the role of circRNAs in NSCLC progression.
Other information
Title:

Circular RNA circ_0000517 Facilitates The Growth and Metastasis of Non-Small Cell Lung Cancer by Sponging miR-326/miR-330-5p.

Journal: Cell J
Published: 2021/11/28
PubMed ID: 34837683