circRNA basic information
circBase ID: hsa_circ_0000527
Name: hsa_circ_FAM158A
Synonym: circ_0000527
Host Gene: hsa-miR-27a-3p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: Retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: RB cell lines (Y79, WERI-Rb1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HDAC9
Associated microRNA: hsa-miR-27a-3p
Biological function: Hsa_circ_0000527 downregulation repressed RB cell proliferation and induced RB cell apoptosis.
Molecular mechanism: hsa-miR-27a-3p was a target of hsa_circ_0000527, and hsa_circ_0000527 suppressed the expression of hsa-miR-27a-3p. hsa-miR-27a-3p inhibition reversed the role of hsa_circ_0000527 downregulation. In addition, HDAC9 was a target of hsa-miR-27a-3p, and hsa_circ_0000527 indirectly regulated HDAC9 expression by targeting hsa-miR-27a-3p. hsa-miR-27a-3p restoration inhibited RB cell proliferation and promoted apoptosis, which was reversed by HDAC9 overexpression. Hsa_circ_0000527 downregulation could inactivate the PI3K/AKT pathway. Moreover, hsa_circ_0000527 downregulation blocked tumor growth rate_n vivo.
Survival: -
Supported No.:
 5
Description:

hsa_circ_0000527 downregulation blocked the progression of RB by regulating the miR-27a-3p/HDAC9 pathway, which might be associated with the inactivation of the PI3K/AKT pathway.
Other information
Title:

Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway.

Journal: Curr Eye Res
Published: 2021/11/27
PubMed ID: 34823425