circRNA basic information
circBase ID: -
Name: hsa_circ_RBM33
Synonym: circRBM33
Host Gene: hsa-miR-4268
 
 
 
Disease basic information
DO ID:
 7693
DO name: abdominal aortic aneurysm
Disease details: abdominal aortic aneurysm
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: EPHB2
Associated microRNA: hsa-miR-4268
Biological function: Overexpression of circRBM33 increased the expression of ECM-related molecule matrix metalloproteinase-2 and reduced the tissue inhibitor of matrix metalloproteinases-1 expression.
Molecular mechanism: hsa-miR-4268 targeted binding to circRBM33 and inhibited the luciferase activity of circRBM33. Overexpression of circRBM33 induced the expression of EPH receptor B2 (EPHB2), and this effect was countered by hsa-miR-4268 mimics.
Survival: -
Supported No.:
 1
Description:

circRBM33 might be involved in AAA progression by regulating ECM degradation_ia_he miR-4268/EPHB2 axis.
Other information
Title:

Circular RNA RBM33 contributes to extracellular matrix degradation via miR-4268/EPHB2 axis in abdominal aortic aneurysm.

Journal: PeerJ
Published: 2021/11/26
PubMed ID: 34820156