circRNA basic information
circBase ID: hsa_circ_0030235
Name: -
Synonym: Circ_0030235
Host Gene: hsa-miR-526b
 
 
 
Disease basic information
DO ID:
 9408
DO name: acute myocardial infarction
Disease details: acute myocardial Infarction
Species: human
Species details: human
Sample type: cell line
Sample type details: rat cardiomyocyte cell line (H9c2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-526b
Biological function: Circ_0030235 was highly expressed in OGD/R-induced H9c2 cells. OGD/R inducement cell viability, while accelerated apoptosis. Besides, the level ROS, cell injury-related factors, mitochondrial membrane potential were notably elevated by OGD/R inducement, while mitochondrial viability was remarkably declined. Whereas, these impacts were all noticeably remitted by circ_0030235 knockdown.
Molecular mechanism: miR-526b was a target of circ_0030235. Circ_0030235 knockdown-induced impacts were all notably abrogated by hsa-miR-526b inhibition, including the activating impacts on PI3K/AKT and MEK/ERK pathways.
Survival: -
Supported No.:
 1
Description:

This research implied that circ_0030235 knockdown might remit OGD/R-induced impacts via activation of PI3K/AKT and MEK/ERK pathways and regulation of miR-526b.
Other information
Title:

Circ_0030235 knockdown protects H9c2 cells against OGD/R-induced injury via regulation of miR-526b.

Journal: PeerJ
Published: 2021/11/26
PubMed ID: 34820154