circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1as
Synonym: circCDR1as
Host Gene: -
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cells (Cal-27, SCC9), 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Overexpression of circCDR1as promoted autophagy, cell cycle, proliferation, and metastasis and repressed apoptosis in OSCC cells.
Molecular mechanism: circCDR1as directly targeted hsa-miR-876-5p and hsa-miR-876-5p interacted with SLC7A11. hsa-miR-876-5p overexpression reversed the effects of circCDR1as elevation on OSCC cell autophagy, cell cycle, growth, motility, and apoptosis. Inhibition of hsa-miR-876-5p aggravated the malignant behaviors of OSCC cells, while SLC7A11 silencing ameliorated the impacts. In addition, circCDR1as knockdown blocked tumor growth in vivo.
Survival: -
Supported No.:
 1
Description:

CircCDR1as acted as an oncogene in OSCC progression through elevating SLC7A11 by targeting miR-876-5p.
Other information
Title:

Overexpression of circCDR1as drives oral squamous cell carcinoma progression.

Journal: Oral Dis
Published: 2021/11/25
PubMed ID: 34817912