circRNA basic information
circBase ID: -
Name: hsa_circ_CREBBP
Synonym: Circ-CREBBP
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cells (LN18, T98, A172, LN229, U251), normal human astrocytes (NHA)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: glutaminase
Associated microRNA: hsa-miR-375
Biological function: Effects of circ-CREBBP on cell malignant phenotypes and glutamine catabolism of glioma in vitro,Circ-CREBBP knockdown impedes glioma tumor growth in vivo
Molecular mechanism: hsa-miR-375 is a target of circ-CREBBP,Circ-CREBBP knockdown suppresses glioma progression via targeting hsa-miR-375
Survival: poor
Supported No.:
 1
Description:

In conclusion, this research uncovered that circ-CREBBP exerted oncogenic role to promote glioma cell growth, migration, invasion and glutamine metabolism in vitro and imped tumor growth in nude mice via miR-375/GLS axis, elucidating the potential role of glutamine metabolism in cancer targeted therapies, which provided a novel insight into the development of novel therapeutic strategies for glioma patients.
Other information
Title:

Circ-CREBBP promotes cell tumorigenesis and glutamine catabolism in glioma by regulating miR-375/glutaminase axis.

Journal: Brain Res
Published: 2021/11/24
PubMed ID: 34813772