circRNA basic information
circBase ID: -
Name: hsa_circ_KDM4C
Synonym: circKDM4C
Host Gene: hsa-miR-200bc-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: UM-UC3, T24, SV-HUC-1
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: hsa-miR-200bc-3p
Biological function: circKDM4C enhances BCa cell invasion and metastasis in vitro and in vivo
Molecular mechanism: circKDM4C serves as a sponge for hsa-miR-200b-3p/hsa-miR-200c-3p in BCa cells,hsa-miR-200b-3p and hsa-miR-200c-3p suppress BCa cell invasion and metastasis via targeting ZEB1,circKDM4C regulates ZEB1 expression and enhances BCa progression via sponging hsa-miR-200b-3p and hsa-miR-200c-3p
Survival: -
Supported No.:
 1
Description:

circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer.
Other information
Title:

circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis.

Journal: Cell Death Discov
Published: 2021/11/24
PubMed ID: 34811353