circRNA basic information
circBase ID: hsa_circ_008877
Name: hsa_circ_PTPDC1
Synonym: Circ-PTPDC1
Host Gene: hsa-miR-139-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GC cell lines (AGS, MKN28, SGC-7901, MKN-45, MGC-803)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: ELK1
Associated microRNA: hsa-miR-139-3p
Biological function: Circ-PTPDC1 is associated with clinicopathological parameters of GC patients,Circ-PTPDC1 expression level alters proliferation, invasion and migration of GC cells
Molecular mechanism: Circ-PTPDC1 serves as a sponge for hsa-miR-139-3p and hsa-miR-139-3p suppresses the proliferation, migration and invasion of GC cells,Circ-PTPDC1 directly binds to hsa-miR-139-3p to further target ELK1
Survival: poor
Supported No.:
 1
Description:

Our study identifies a new circular RNA, termed circ-PTPDC1 that is up-regulated in tumor tissues, cells and plasma of GC patients, and can act as a sponge of miR-139-3p to regulate the expression of ELK1. Our findings suggest that circ-PTPDC1 may be a novel potential circulating biomarker for the detection of GC.
Other information
Title:

Circ-PTPDC1 promotes the Progression of Gastric Cancer through Sponging Mir-139-3p by Regulating ELK1 and Functions as a Prognostic Biomarker.

Journal: Int J Biol Sci
Published: 2021/11/23
PubMed ID: 34803498