circRNA basic information
circBase ID: hsa_circ_0043278
Name: hsa_circ_TADA2A
Synonym: -
Host Gene: hsa-miR-455-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human BC cell lines (MDA-MB-231, MCF-7), a normal mammary epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: EI24
Associated microRNA: hsa-miR-455-3p
Biological function: overexpression of hsa_circ_0043278 notably decreased BC cell viability and inhibited BC cell migration and invasion in vitro and suppressed tumour growth in vivo. Downregulation of hsa_circ_0043278 led to the opposite results.
Molecular mechanism: Hsa_circ_0043278 expression was negatively correlated with that of hsa-miR-455-3p. In addition, mechanistic investigation proved that hsa_circ_0043278 directly bound to hsa-miR-455-3p and regulated EI24 and NF-¦ĘB expression in BC cells.
Survival: better
Supported No.:
 4
Description:

Hsa_circ_0043278 acts as a tumour suppressor gene in BC through the hsa_circ_0043278/miR-455-3p/EI24 axis and may be regarded as a new prognostic predictor or potential therapeutic target in BC.
Other information
Title:

Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway.

Journal: BMC Cancer
Published: 2021/11/22
PubMed ID: 34800978