circRNA basic information
circBase ID: -
Name: hsa_circ_METTL15
Synonym: Circ-METTL15
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal bronchial epithelial cell line (HBE), lung cancer cell lines (H460, H1650, H1299, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDL1
Associated microRNA: hsa-miR-1299
Biological function: Circ-METTL15 silencing suppressed cell proliferation, colony formation, invasion, immune escape and promoted cell apoptosis in lung cancer cells.
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Circ-METTL15 promoted lung cancer malignant progression at least partly through modulating PDL1 by sponging miR-1299.
Other information
Title:

Circ-METTL15 contributes to the proliferation, metastasis, immune escape and restrains apoptosis in lung cancer by regulating miR-1299/PDL1 axis.

Journal: Autoimmunity
Published: 2021/11/20
PubMed ID: 34796777