circRNA basic information
circBase ID: hsa_circ_0006174
Name: hsa_circ_RAD23B
Synonym: circ_0006174
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (LoVo, HCT116)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND2
Associated microRNA: hsa-miR-1205
Biological function: Knockdown of circ_0006174 reduced DOX resistance, cell proliferation, migration, and invasion in DOX-resistant CRC cells
Molecular mechanism: -
Survival: -
Supported No.:
 5
Description:

To conclude, this study manifested that exosome-mediated delivery of circ_0006174 could confer DOX resistance to CRC cells via regulating the miR-1205/CCND2 signal pathway. Exosomal circ_0006174 can serve as a useful diagnostic target for DOX resistance..
Other information
Title:

Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis.

Journal: J Physiol Biochem
Published: 2021/11/19
PubMed ID: 34792792