circRNA basic information
circBase ID: -
Name: hsa_circ_NOTCH3
Synonym: circ_NOTCH3
Host Gene: hsa-miR-875-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human liver cells LO2, HCC cells (HUH7, HepG2, 7721, together with LM3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZNF146
Associated microRNA: hsa-miR-875-5p
Biological function: Silencing circ_NOTCH3 restrains the growth of HCC
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

As an oncogene, circ_NOTCH3 can trigger the proliferation, invasion, migration, and oxaliplatin resistance of HCC cells through the miR-875-5p/ZNF146 axis, and may be a promising target for the treatment of HCC.
Other information
Title:

Hsa_circ_NOTCH3 regulates ZNF146 through sponge adsorption of miR-875-5p to promote tumorigenesis of hepatocellular carcinoma.

Journal: J Gastrointest Oncol
Published: 2021/11/19
PubMed ID: 34790400