circRNA basic information
circBase ID: -
Name: hsa_circ_NOLC1
Synonym: circNOLC1
Host Gene: hsa-miR-365a-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human BC cell lines (MDA-MB-231, MDA-MB-468)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: hsa-miR-365a-3p
Biological function: The inhibition of circNOLC1 represses breast cancer proliferation in vitro.The inhibition of circNOLC1 inhibits breast cancer migration and epithelial-mesenchymal transition in vitro.
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circNOLC1 contributed to CSCs properties and progression of breast cancer by targeting miR-365a-3p /STAT3 axis and propofol inhibited circNOLC1 by repressing STAT3 in a feedback mechanism.
Other information
Title:

The inhibition of circular RNA circNOLC1 by propofol/STAT3 attenuates breast cancer stem cells function via miR-365a-3p/STAT3 signaling.

Journal: J Transl Med
Published: 2021/11/19
PubMed ID: 34789263