circRNA basic information
circBase ID: hsa_circ_0048764
Name: hsa_circ_RPL36
Synonym: circ_0048764
Host Gene: hsa-miR-1296-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human embryonic kidney cells (HEK293T), human BC cell lines (MCF7, SKBR3, MDA-MB-231), human mammary epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRIM14
Associated microRNA: hsa-miR-1296-5p
Biological function: Circ_0048764 promotes the proliferative, migrative, and invasive abilities, and inhibits the apoptosis of BC cell
Molecular mechanism: -
Survival: -
Supported No.:
 2
Description:

In summary, circ_0048764 expression level is elevated in BC tissues and cell lines. In addition, circ_0048764 can expedite BC cell growth, migration, and invasion, and inhibit apoptosis via regulating the miR-1296-5p/TRIM14 axis. It is expected to provide new ideas for the diagnosing and treating BC.
Other information
Title:

Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.

Journal: Bioengineered
Published: 2021/11/18
PubMed ID: 34787066