circRNA basic information
circBase ID: -
Name: hsa_circ_UBR1
Synonym: circ-UBR1
Host Gene: hsa-miR-545-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LC cell lines (H1299, H460, H520, A549), human normal lung epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SSFA2
Associated microRNA: hsa-miR-545-5p
Biological function: Circ-UBR1/miR-545-5p/SSFA2 axis takes part in LC occurrence and advancement
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

In summary, the study of miR-545-5p/SSFA2 axis elucidates the carcinogenic role of circ-UBR1 in the progression of LC. This mechanism may be beneficial to the cognition of the pathogenesis of LC.
Other information
Title:

Circular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis.

Journal: Bioengineered
Published: 2021/11/18
PubMed ID: 34787049