circRNA basic information
circBase ID: hsa_circ_0025033
Name: hsa_circ_FOXM1
Synonym: CircFOXM1
Host Gene: hsa-miR-577
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GBM cell lines (U251, LN229, T98, A172), normal astrocytes (NHAs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F5
Associated microRNA: hsa-miR-577
Biological function: Silencing of circFOXM1 inhibited the proliferation, migration, invasion, and glutaminolysis of GBM cells in vitro
Molecular mechanism: CircFOXM1 served as a molecular sponge of hsa-miR-577
Survival: -
Supported No.:
 1
Description:

Collectively, our results proposed that circFOXM1 was an upregulated circRNA in GBM, which could facilitate the proliferation, metastasis, and glutaminolysis of GBM through regulating the miR-577/E2F5 axis.
Other information
Title:

CircFOXM1 promotes the proliferation, migration, invasion, and glutaminolysis of glioblastoma by regulating the miR-577/E2F5 axis.

Journal: Bosn J Basic Med Sci
Published: 2021/11/17
PubMed ID: 34784267