circRNA basic information
circBase ID: hsa_circ_0007113
Name: hsa_circ_HERC4
Synonym: circHERC4
Host Gene: hsa-miR-556-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC cell lines (HCT116, DLD-1, HT29, LoVo, SW480), normal colonic epithelial cells (HCoEpic)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CTBP2, E-cadherin
Associated microRNA: hsa-miR-556-5p
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

CircHERC4 exerts critical roles in promoting tumor aggressiveness through miR-556-5p/CTBP2/E-cadherin pathway and is a prognostic biomarker of the disease, suggesting that circHERC4 may serve as an exploitable therapeutic target for patients with CRC.
Other information
Title:

Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer.

Journal: J Hematol Oncol
Published: 2021/11/17
PubMed ID: 34781990