circRNA basic information
circBase ID: hsa_circ_0080145
Name: hsa_circ_TNS3
Synonym: circ_0080145
Host Gene: hsa-miR-203
 
 
 
Disease basic information
DO ID:
 8552
DO name: chronic myeloid leukemia
Disease details: chronic myeloid leukemia
Species: human
Species details: human
Sample type: cell line
Sample type details: K562 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABL1
Associated microRNA: hsa-miR-203
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 3
Description:

This study established the signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1. The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637.
Other information
Title:

Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1.

Journal: Mol Med
Published: 2021/11/17
PubMed ID: 34781898