circRNA basic information
circBase ID: hsa_circ_0007294
Name: hsa_circ_ANKS1B
Synonym: circ_0007294
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human OSCC cell lines (CAL27, SCC9, SCC090)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TGF-beta1
Associated microRNA: hsa-miR-515-5p
Biological function: Knockdown of circANKS1B suppresses OSCC cell invasion and migration
Molecular mechanism: circANKS1B positively regulates TGF-beta1 expression in OSCC cell lines
Survival: -
Supported No.:
 1
Description:

circANKS1B suppression elicited the anti-carcinogenic properties in OSCC cell invasion, migration, and cisplatin resistance by sponging miR-515-5p to block TGF-beta. Therefore, circANKS1B may act as an oncogenic gene to evoke TGF-beta signaling to participate in the development of OSCC.
Other information
Title:

Regulation of transforming growth factor-beta1 by circANKS1B/miR-515-5p affects the metastatic potential and cisplatin resistance in oral squamous cell carcinoma.

Journal: Bioengineered
Published: 2021/11/17
PubMed ID: 34781814