circRNA basic information
circBase ID: hsa_circ_0000745
Name: hsa_circ_SPECC1
Synonym: Circ_0000745
Host Gene: hsa-miR-193b-3p
 
 
 
Disease basic information
DO ID:
 5603
DO name: T-cell acute lymphoblastic leukemia
Disease details: T-cell acute lymphoblastic leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NOTCH1
Associated microRNA: hsa-miR-193b-3p
Biological function: both circ_0000745 and NOTCH1 overexpression promoted T-ALL cell proliferation and curbed T-ALL cell apoptosis
Molecular mechanism: circ_0000745 regulated NOTCH1 expression by sponging hsa-miR-193b-3p
Survival: -
Supported No.:
 1
Description:

circ_0000745 promoted cell proliferation and curbed cell apoptosis via upregulating NOTCH1 through serving as a miR-193b-3p sponge in T-ALL.
Other information
Title:

Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p.

Journal: Hematology
Published: 2021/11/11
PubMed ID: 34753401