circRNA basic information
circBase ID: hsa_circ_0058106
Name: hsa_circ_MMP11
Synonym: Circ_0058106
Host Gene: hsa-miR-185-3p
 
 
 
Disease basic information
DO ID:
 8533
DO name: hypopharynx cancer
Disease details: hypopharyngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: Wnt2b/beta-catenin/c-Myc pathway
Associated microRNA: hsa-miR-185-3p
Biological function: circ_0058106 upregulation promoted proliferation, migration and invasion of HSCC cells, while knockdown of circ_0058106 inhibited proliferation, migration and invasion of HSCC cells both in vitro and in vivo
Molecular mechanism: by regulating Wnt2b/beta-catenin/c-Myc pathway via hsa-miR-185-3p
Survival: -
Supported No.:
 2
Description:

our findings firstly confirmed the carcinogenic effect of circ_0058106 in promoting HSCC cells tumorigenesis, metastasis, invasion and EMT process by regulating Wnt2b/beta-catenin/c-Myc pathway through sponging miR-185-3p, indicating that circ_0058106 may be a new therapeutic target and prognostic marker for HSCC.
Other information
Title:

Circ_0058106 promotes proliferation, metastasis and EMT process by regulating Wnt2b/beta-catenin/c-Myc pathway through miR-185-3p in hypopharyngeal squamous cell carcinoma.

Journal: Cell Death Dis
Published: 2021/11/10
PubMed ID: 34750351