circRNA basic information
circBase ID: -
Name: hsa_circ_SEPT9
Synonym: circSEPT9
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal breast cells (MCF-10A), BC cell lines (MDA-MB-231, BT-549), human embryonic kidney cells (293_)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SLC1A5
Associated microRNA: hsa-miR-149-5p
Biological function: Knockdown of circSEPT9 or SLC1A5 inhibited glutamine uptake and cell proliferation, but induced cell apoptosis in BC cells
Molecular mechanism: circSEPT9 regulated SLC1A5 expression by sponging hsa-miR-149-5p
Survival: -
Supported No.:
 1
Description:

circSEPT9 may act an oncogenic role in BC malignant progression by regulating miR-149-5p/SLC1A5 pathway, providing a novel mechanism responsible for BC development.
Other information
Title:

Knockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner.

Journal: Bioengineered
Published: 2021/11/6
PubMed ID: 34738502