circRNA basic information
circBase ID: hsa_circ_0004442
Name: hsa_circ_TLK1
Synonym: circTLK1
Host Gene: hsa-miR-126-5p, hsa-miR-204-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: Diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human mesangial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT
Associated microRNA: hsa-miR-126-5p, hsa-miR-204-5p
Biological function: circTLK1 inhibition reduced HG-induced inflammation, oxidative stress, and ECM accumulation in human mesangial cells.
Molecular mechanism: CircTLK1 was verified as a sponge for miR-126-5p and miR-204-5p, which were downregulated in DN patient serum and HG-treated human mesangial cells.
Survival: -
Supported No.:
 1
Description:

CircTLK1 downregulation alleviated HG-induced inflammation, oxidative stress, and ECM accumulation through blocking the AKT/NF-¦ĘB pathway via sponging miR-126-5p/miR-204-5p, providing a new mechanism to comprehend the pathogenesis of DN.
Other information
Title:

CircTLK1 Downregulation Attenuates High Glucose-Induced Human Mesangial Cell Injury by Blocking the AKT/NF-kappaB Pathway Through Sponging miR-126-5p/miR-204-5p.

Journal: Biochem Genet
Published: 2021/11/4
PubMed ID: 34731387