circRNA basic information
circBase ID: hsa_circ_0002346
Name: -
Synonym: circ_0002346
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal lung epithelial cell line (HBE), NSCLC cell lines (A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: STXBP6
Associated microRNA: hsa-miR-582-3p
Biological function: circ_0002346 overexpression significantly suppressed the proliferation, migration, invasion, and glycolysis and triggered the apoptosis of NSCLC cells
Molecular mechanism: circ_0002346 can upregulate the expression of STXBP6 by acting as a hsa-miR-582-3p sponge in NSCLC cells
Survival: -
Supported No.:
 2
Description:

circ_0002346 overexpression suppressed the malignant properties of NSCLC cells by binding to miR-582-3p to induce the expression of STXBP6.
Other information
Title:

circ_0002346 Suppresses Non-Small-Cell Lung Cancer Progression Depending on the Regulation of the miR-582-3p/STXBP6 Axis.

Journal: Int J Genomics
Published: 2021/11/2
PubMed ID: 34722753