circRNA basic information
circBase ID: hsa_circ_0000006
Name: -
Synonym: circ_0000006
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BDNF
Associated microRNA: hsa-miR-646
Biological function: Circ_0000006 knockdown repressed cell proliferation, migration and invasion, whereas promoted cell apoptosis under DOX treatment in OS cells; however, these effects were attenuated by miR-646 inhibitor
Molecular mechanism: circ_0000006 sponged hsa-miR-646 to bind to BDNF
Survival: -
Supported No.:
 2
Description:

Circ_0000006 knockdown promoted DOX-mediated effects on OS development by miR-646/BDNF pathway, which provided a theoretical basis in treating OS with DOX.
Other information
Title:

Doxorubicin inhibits osteosarcoma progression by regulating circ_0000006/miR-646/ BDNF axis.

Journal: J Orthop Surg Res
Published: 2021/11/1
PubMed ID: 34717683