circRNA basic information
circBase ID: -
Name: hsa_circ_PRKAR1B
Synonym: circPRKAR1B
Host Gene: hsa-miR-361-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD4
Associated microRNA: hsa-miR-361-3p
Biological function: circPRKAR1B enhanced OS cell proliferation, migration, and promotes OS epithelial-mesenchymal transition (EMT)
Molecular mechanism: circPRKAR1B promotes OS progression through sponging hsa-miR-361-3p to modulate the expression of FZD4
Survival: -
Supported No.:
 1
Description:

circPRKAR1B exerted oncogenic roles in OS and suggested the circPRKAR1B/miR-361-3p/FZD4 axis plays an important role in OS progression and might be a potential therapeutic target.
Other information
Title:

EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression.

Journal: Cell Death Dis
Published: 2021/10/31
PubMed ID: 34716310