circRNA basic information
circBase ID: hsa_circ_0078767
Name: hsa_circ_FAM120B
Synonym: CircFAM120B
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human OS cell lines (MG63, U2OS, 143B, HOS, SJSA-1), osteoblasts (hFOB 1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PTBP1
Associated microRNA: hsa-miR-1205
Biological function: Silenced circFAM120B significantly suppressed in vitro OS cell proliferation and invasion, and inhibited in vivo tumor growth
Molecular mechanism: CircFAM120B also appeared to function as an hsa-miR-1205 sponge, as hsa-miR-1205 bound to PTBP1
Survival: -
Supported No.:
 3
Description:

We hypothesize circFAM120B functions as a miR-1205 sponge to elevate PTBP1 levels, enhancing OS progression and associated malignant phenotypes.

Other information
Title:

CircFAM120B knockdown inhibits osteosarcoma tumorigenesis via the miR-1205/PTBP1 axis.

Journal: Aging (Albany NY)
Published: 2021/10/31
PubMed ID: 34716285