circRNA basic information
circBase ID: hsa_circ_0065217
Name: hsa_circ_SCAP
Synonym: -
Host Gene: hsa-miR-214-3p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RCC cell lines (ACHN, SW839, OS-RC-2, A498, 786-O, Caki-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ALPK2
Associated microRNA: hsa-miR-214-3p
Biological function: Hsa_circ_0065217 silencing reduced in vitro RCC cell-line growth and aggressiveness
Molecular mechanism: hsa_circ_0065217 promoted alpha protein kinase 2 (ALPK2) expression via its competing endogenous RNA (ceRNA) activity toward hsa-miR-214-3p
Survival: -
Supported No.:
 1
Description:

hsa_circ_0065217/miR-214-3p/ALPK2 signaling putatively promotes RCC tumorigenesis and is a putative RCC treatment target.
Other information
Title:

Hsa_circ_0065217 promotes growth and metastasis of renal cancer through regulating the miR-214-3p-ALPK2 axis.

Journal: Cell Cycle
Published: 2021/10/28
PubMed ID: 34705617