circRNA basic information
circBase ID: hsa_circ_0004296
Name: hsa_circ_ETS1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ETS1
Associated microRNA: -
Biological function: circ_0004296 inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition of PCa cells
Molecular mechanism: circ_0004296 regulated host gene ETS1 expression at the post-transcriptional level
Survival: better
Supported No.:
 1
Description:

Circ_0004296 overexpression efficiently inhibited ETS1 mRNA nuclear export by promoting EIF4A3 retention in the nucleus, leading to the downregulation of ETS1 expression and suppression of PCa metastasis; thus, circ_0004296 might be a potential biomarker and therapeutic target for patients with PCa.
Other information
Title:

Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA.

Journal: J Exp Clin Cancer Res
Published: 2021/10/27
PubMed ID: 34696782