circRNA basic information
circBase ID: hsa_circ_0001658
Name: -
Synonym: Circ_0001658
Host Gene: hsa-miR-409-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TWIST1
Associated microRNA: hsa-miR-409-3p
Biological function: Knocking down circ_0001658 could restrain the viability of NSCLC cells, promote the apoptosis, and reduce the IC50 of gefitinib, while transfection of miR-409-3p inhibitors could partially reverse these impacts
Molecular mechanism: by regulating the hsa-miR-409-3p/TWIST1 axis
Survival: poor
Supported No.:
 1
Description:

Circ_0001658 promotes the malignant phenotypes and the resistance to gefitinib of NSCLC cells by regulating the miR-409-3p/TWIST1 axis.
Other information
Title:

Circ_0001658 regulates gefitinib resistance of non-small cell lung cancer through miR-409-3p/TWIST1 axis.

Journal: Anticancer Drugs
Published: 2021/10/26
PubMed ID: 34694278