circRNA basic information
circBase ID: hsa_circ_0003221
Name: hsa_circ_PTK2
Synonym: CircPTK2
Host Gene: hsa-miR-1278
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human LSCC cell lines (SNU899, SNU46)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: hsa-miR-1278
Biological function: knockdown of circPTK2 suppressed LSCC cell viability and the cell cycle while promoting cell apoptosis.
Molecular mechanism: circPTK2 functioned as a molecular sponge of hsa-miR-1278 to upregulate YAP1 expression in LSCC cells
Survival: -
Supported No.:
 1
Description:

circPTK2 facilitates LSCC progression through the miR-1278/YAP1 axis.
Other information
Title:

CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by the miR-1278/YAP1 Axis.

Journal: J Oncol
Published: 2021/10/26
PubMed ID: 34691176