circRNA basic information
circBase ID: hsa_circ_0006852
Name: hsa_circ_CORO1C
Synonym: circCORO1C
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PD-L1
Associated microRNA: -
Biological function: the overexpression of circCORO1C can enhance the proliferation and metastasis ability of HCC cells
Molecular mechanism: circCORO1C activated the NF-kappaB signaling pathway, increased P65 phosphorylation and upregulation of c-Myc and COX-2, leading to increased PD-L1 expression
Survival: -
Supported No.:
 3
Description:

CircCORO1C upregulates c-Myc and COX-2 through NF-kappaB signaling pathway, leading to the upregulation of PD-L1, which jointly promotes the development of HCC, suggesting that circCORO1C is a promising biomarker and therapeutic target for HCC.
Other information
Title:

circCORO1C promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing the expression of PD-L1 through NF-kappaB pathway.

Journal: J Clin Lab Anal
Published: 2021/10/23
PubMed ID: 34676904