circRNA basic information
circBase ID: hsa_circ_0026416
Name: -
Synonym: Circ_0026416
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MYO6
Associated microRNA: hsa-miR-545-3p
Biological function: Circ_0026416 downregulation inhibited CRC cell proliferation, colony formation, migration, invasion, and EMT but induced cell apoptosis in vitro
Molecular mechanism: circ_0026416 knockdown depleted MYO6 expression by enriching hsa-miR-545-3p
Survival: -
Supported No.:
 1
Description:

Circ_0026416 downregulation inhibits CRC development in vitro and in vivo. 2. Circ_0026416 regulates the expression of MYO6 by targeting miR-545-3p. 3. Circ_0026416 governs the miR-545-3p/MYO6 axis to regulate CRC progression.
Other information
Title:

Circ_0026416 downregulation blocks the development of colorectal cancer through depleting MYO6 expression by enriching miR-545-3p.

Journal: World J Surg Oncol
Published: 2021/10/15
PubMed ID: 34645476